anti-STAT5A antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes STAT5A
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: STAT5A
  • 抗原物种: Human
  • 抗原: A synthetic peptide corresponding to C-terminal sequence of human Stat5a.
  • Brand:
CAT.NO. : ARG62629
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes STAT5A
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称STAT5A
抗原物种Human
抗原A synthetic peptide corresponding to C-terminal sequence of human Stat5a.
抗原表位C-terminal
偶联标记Un-conjugated
別名Signal transducer and activator of transcription 5A; STAT5; MGF
应用说明
应用建议
应用推荐稀释比
IHC-P1:400
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照A431 cells. Tonsil.
属性
形式Liquid
纯化Purified Antibody
缓冲液1X PBS and 0.1% Sodium azide
抗菌剂0.1% Sodium azide
浓度0.2 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 20850 Mouse STAT5A

GeneID: 24918 Rat STAT5A

GeneID: 6776 Human STAT5A

基因名称STAT5A
全名signal transducer and activator of transcription 5A
背景介绍The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
生物功能Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. [UniProt]
研究领域Gene Regulation antibody; Signaling Transduction antibody
预测分子量91 kDa
翻译后修饰Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.
ISGylated.
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