anti-STK24 / MST3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59562
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STK24 / MST3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STK24 / MST3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 312-431 of Human STK24 / MST3 (NP_001027467.2). |
| 偶联标记 | Un-conjugated |
| 別名 | STE20-like kinase MST3; Mammalian STE20-like protein kinase 3 N-terminal; MST3/N; MST3B; STE20; Mammalian STE20-like protein kinase 3 C-terminal; HEL-S-95; MST3; Mammalian STE20-like protein kinase 3; STK3; MST-3; EC 2.7.11.1; MST3/C; Serine/threonine-protein kinase 24 |
应用说明
| 预测反应性说明 | Rat | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse lung and U-251MG. | ||||||||
| 实际分子量 | 49 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | STK24 |
| 全名 | serine/threonine kinase 24 |
| 背景介绍 | This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
| 生物功能 | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus, Membrane. [UniProt] |
| 预测分子量 | 49 kDa |
| 翻译后修饰 | Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis. Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues. [UniProt] |
检测图片 (1)
ARG59562 anti-STK24 / MST3 antibody WB image
Western blot: 25 µg of Mouse lung and U-251MG cell lysates stained with ARG59562 anti-STK24 / MST3 antibody at 1:1000 dilution.
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