anti-STRAP / Unrip antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG59369
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STRAP / Unrip |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Bov, Chk |
| 应用 | FACS, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STRAP / Unrip |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 242-269 of Human STRAP / Unrip. |
| 偶联标记 | Un-conjugated |
| 別名 | WD-40 repeat protein PT-WD; UNRIP; MAWD; UNR-interacting protein; Serine-threonine kinase receptor-associated protein; PT-WD; MAP activator with WD repeats |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y3F4 Human Serine-threonine kinase receptor-associated protein |
|---|---|
| 基因名称 | STRAP |
| 全名 | serine/threonine kinase receptor associated protein |
| 生物功能 | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus. [UniProt] |
| 预测分子量 | 38 kDa |
检测图片 (2)
ARG59369 anti-STRAP / Unrip antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human brain tissue stained with ARG59369 anti-STRAP / Unrip antibody.
ARG59369 anti-STRAP / Unrip antibody FACS image
Flow Cytometry: HeLa cells stained with ARG59369 anti-STRAP / Unrip antibody (bottom histogram) or without primary antibody as control (top histogram), followed by incubation with FITC labelled secondary antibody.
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