anti-SUB1 / PC4 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59257
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SUB1 / PC4 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SUB1 / PC4 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-127 of Human SUB1 / PC4 (NP_006704.3). |
| 偶联标记 | Un-conjugated |
| 別名 | Positive cofactor 4; Activated RNA polymerase II transcriptional coactivator p15; PC4; p14; P15; SUB1 homolog |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HL60 | ||||||||
| 实际分子量 | 16 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P11031 Mouse Activated RNA polymerase II transcriptional coactivator p15 Swiss-port # P53999 Human Activated RNA polymerase II transcriptional coactivator p15 |
|---|---|
| 基因名称 | SUB1 |
| 全名 | SUB1 homolog, transcriptional regulator |
| 生物功能 | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 14 kDa |
| 翻译后修饰 | Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region. [UniProt] |
检测图片 (3)
ARG59257 anti-SUB1 / PC4 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG59257 anti-SUB1 / PC4 antibody.
ARG59257 anti-SUB1 / PC4 antibody WB image
Western blot: 25 µg of HL60 cell lysate stained with ARG59257 anti-SUB1 / PC4 antibody at 1:1000 dilution.
ARG59257 anti-SUB1 / PC4 antibody IP image
Immunoprecipitation: 150 µg extracts of HL60 cells were immunoprecipitated and stained with ARG59257 anti-SUB1 / PC4 antibody at 1:500 dilution.
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