anti-Syntaxin antibody [STX01 (HPC-1)]
![anti-Syntaxin antibody [STX01 (HPC-1)]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG62633
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [STX01 (HPC-1)] recognizes Syntaxin |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | STX01 (HPC-1) |
| 同位型 | IgG1 |
| 靶点名称 | Syntaxin |
| 抗原物种 | Rat |
| 抗原 | amino acids 3-225- raised against Syntaxin 1 of rat origin |
| 偶联标记 | Un-conjugated |
| 別名 | HPC-1; STX1; Syntaxin-1A; SYN1A; Neuron-specific antigen HPC-1; P35-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | SH-SY5Y cell lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified Antibody |
| 缓冲液 | 1X PBS and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Stx1a |
| 全名 | syntaxin 1A (brain) |
| 背景介绍 | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| 生物功能 | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [UniProt] |
| 研究领域 | Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. |
参考文献
克隆号文献
Amacrine cell subtypes differ in their intrinsic neurite growth capacity.
IHC / Rat
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex.
IHC-P / Rat
Foxn4 is required for retinal ganglion cell distal axon patterning.
IHC / Mouse
Amacrine cell gene expression and survival signaling: differences from neighboring retinal ganglion cells.
ICC/IF / Rat
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