anti-Syntrophin antibody

Key features and details

  • 产品描述: Goat Polyclonal antibody recognizes Syntrophin
  • 反应物种: Hu, Ms, Rat
  • 预测物种: Cow, Dog, Pig
  • 应用: WB
  • 宿主: Goat
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Syntrophin
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG63381
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Product Details
概述
产品描述Goat Polyclonal antibody recognizes Syntrophin
反应物种Hu, Ms, Rat
预测物种Cow, Dog, Pig
应用WB
宿主Goat
克隆Polyclonal
同位型IgG
靶点名称Syntrophin
抗原物种Human
抗原ASGRRAPRTGLLE-C
偶联标记Un-conjugated
別名dJ1187J4.5; Syntrophin-1; SNT1; LQT12; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; Alpha-1-syntrophin; TACIP1
应用说明
应用建议
应用推荐稀释比
WB1 - 3 µg/ml
应用说明WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
缓冲液Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
抗菌剂0.02% Sodium azide
稳定剂0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 6640 Human SNTA1

Swiss-port # Q13424 Human Alpha-1-syntrophin

背景介绍Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jul 2012]
研究领域Signaling Transduction antibody
预测分子量54 kDa
翻译后修饰Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
检测图片 (1)
  • ARG63381 anti-Syntrophinantibody WB image

    Western Blot: Human Muscle lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. stained with ARG63381 anti-Syntrophin (alpha 1) antibody at 0.01 µg/ml dilution.

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