anti-TAO2 phospho (Ser181) antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG52440
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TAO2 phospho (Ser181) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Cat, Xenopus laevis, Zfsh |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TAO2 |
| 抗原物种 | Human |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | hKFC-C; PSK; Thousand and one amino acid protein kinase 2; Prostate-derived sterile 20-like kinase 1; MAP3K17; Kinase from chicken homolog C; PSK1; PSK-1; Prostate-derived STE20-like kinase 1; PSK1-BETA; EC 2.7.11.1; Serine/threonine-protein kinase TAO2; TAO1; TAO2 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | Specific for the ~120k TAO2 phosphorylated at Ser181 in Western blots. Immunolabeling is completely eliminated by treatment with λ phosphatase. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TAOK2 |
| 全名 | TAO kinase 2 |
| 背景介绍 | In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain. |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 138 kDa |
| 翻译后修饰 | Isoforms 1 and 2 are autophosphorylated. C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity. Autophosphorylated. Phosphorylated by ATM. Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity). |
检测图片 (1)
ARG52440 anti-TAO2 phospho (Ser181) antibody WB image
Western blot: Rat cortex lysate showing specific immunolabeling of the ~120k TAO2 phosphorylated at Ser181 (Control) stained with ARG52440 anti-TAO2 phospho (Ser181) antibody. The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase).
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