anti-TCL1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG55860
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TCL1A |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TCL1 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 32-66 (Center) of Human TCL1. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein p14 TCL1; Oncogene TCL1; T-cell leukemia/lymphoma protein 1A; TCL1; Oncogene TCL-1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Ramos |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P56279 Human T-cell leukemia/lymphoma protein 1A |
|---|---|
| 基因名称 | TCL1A |
| 全名 | T-cell leukemia/lymphoma 1A |
| 背景介绍 | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
| 生物功能 | Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction |
| 预测分子量 | 13 kDa |
检测图片 (2)
ARG55860 anti-TCL1 antibody WB image
Western blot: 35 µg of Ramos cell lysate stained with ARG55860 anti-TCL1 antibody at 1:1000 dilution.
ARG55860 anti-TCL1 antibody FACS image
Flow Cytometry: Ramos cells stained with ARG55860 anti-TCL1 antibody (right histogram) at 1:25 dilution or isotype control antibody (left histogram), followed by incubation with Alexa Fluor® 488 labelled secondary antibody.
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