anti-TFE3 antibody [SQab21248]
![anti-TFE3 antibody [SQab21248]](/upload/image/products/ARG66881_IHC-P_1_210_205.jpg)
![anti-TFE3 antibody [SQab21248]](/upload/image/products/ARG66881_IHC-P_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG66881
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Product Details
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab21248] recognizes TFE3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab21248 |
| 同位型 | IgG |
| 靶点名称 | TFE3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human TFE3. |
| 偶联标记 | Un-conjugated |
| 別名 | bHLHe33; TFEA; Class E basic helix-loop-helix protein 33; Transcription factor E3; RCCX1; RCCP2 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFE3 |
| 全名 | transcription factor binding to IGHM enhancer 3 |
| 生物功能 | Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 62 kDa |
| 翻译后修饰 | Sumoylated; does not affect dimerization with MITF. [UniProt] |
检测图片 (1)
ARG66881 anti-TFE3 antibody [SQab21248] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human renal cell carcinoma tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66881 anti-TFE3 antibody [SQab21248] for 30 min at RT.
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