anti-TGF beta antibody [1D11.16.8]
![anti-TGF beta antibody [1D11.16.8]](/upload/image/products/ARG56078_210_205.jpg)
![anti-TGF beta antibody [1D11.16.8]](/upload/image/products/ARG56078.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG56078
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [1D11.16.8] recognizes TGF beta |
|---|---|
| 反应物种 | Hu, Ms, Rat, Cow, Dog, Hm, Mk |
| 应用 | ELISA, ICC/IF, IHC-P, Neut, WB |
| 特异性 | This mAb recognizes TGF beta 1, 2 and 3. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1D11.16.8 |
| 同位型 | IgG1, kappa |
| 靶点名称 | TGF beta |
| 抗原物种 | Bovine |
| 抗原 | Bovine TGF-beta2 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | TGF-beta2; Cetermin; LDS4; Polyergin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Transforming growth factor beta-2; LAP; TGF-beta-2; BSC-1 cell growth inhibitor |
应用说明
| 应用建议 |
| ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | WB: It is recommended detct TGF beta under non-reducing conditions. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TGFB2 |
| 全名 | transforming growth factor, beta 2 |
| 背景介绍 | This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010] |
| 生物功能 | TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. [UniProt] |
| 细胞定位 | Cytoplasm and extracellular (secreted) |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. |
检测图片 (1)
ARG56078 anti-TGF beta antibody [1D11.16.8] neutralization image
Neutralization assay: Primary microglial cultures neutralizing with ARG56078 anti-TGF beta antibody [1D11.16.8] at 0.2 μg/mL dilution.
mRNA expression of TNF-α and IL-10 in microglia cultured alone, cocultured with astrocyte by transwell and cultured by ACM in the presence or absence of the anti-TGF-β antibody.From Jinqiang Zhang et al. Front Cell Neurosci (2020), doi: 10.3389/fncel.2020.00195, Fig.8 D and E.
参考文献
Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers.
Neutralizing / Mouse
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