anti-Thioredoxin Reductase 1 antibody [30F1]
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Key features and details
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- 克隆:
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- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG57177
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [30F1] recognizes Thioredoxin Reductase 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 30F1 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | Thioredoxin Reductase 1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 161-647 of Human Thioredoxin Reductase 1 |
| 偶联标记 | Un-conjugated |
| 別名 | Thioredoxin reductase 1, cytoplasmic; EC 1.8.1.9; Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; TR; TXNR; TRXR1; KM-102-derived reductase-like factor; TR1; GRIM-12; Thioredoxin reductase TR1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q16881 Human Thioredoxin reductase 1, cytoplasmic |
|---|---|
| 基因名称 | TXNRD1 |
| 全名 | thioredoxin reductase 1 |
| 背景介绍 | This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. [UniProt] |
| 预测分子量 | 71 kDa |
| 翻译后修饰 | The N-terminus of isoform 5 is blocked. ISGylated. |
检测图片 (3)
ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] ICC/IF image
Immunofluorescence: Hep3B cells line stained with ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] at 1:100 (Green).
DAPI (Blue) for nucleus staining.
ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] WB image
Western blot: 40 µg of 1) HeLa, 2) A549, and 3) PC3 cell lysates stained with ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] at 1:1000.
ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] ICC/IF image
Immunofluorescence: A549 cells line stained with ARG57177 anti-Thioredoxin Reductase 1 antibody [30F1] at 1:100 (Green).
DAPI (Blue) for nucleus staining.
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