anti-Thrombomodulin antibody [THBD/1591]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [THBD/1591] recognizes Thrombomodulin
  • 反应物种: Hu
  • 应用: IHC-P, WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: THBD/1591
  • 同位型: IgG2b, kappa
  • 靶点名称: Thrombomodulin
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG58012
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Product Details
概述
产品描述Mouse Monoclonal antibody [THBD/1591] recognizes Thrombomodulin
反应物种Hu
应用IHC-P, WB
宿主Mouse
克隆Monoclonal
克隆号THBD/1591
同位型IgG2b, kappa
靶点名称Thrombomodulin
抗原物种Human
抗原Recombinant partial protein corresponding to aa. 69-194 of Human Thrombomodulin.
偶联标记Un-conjugated
別名THRM; CD antigen CD141; THPH12; TM; Thrombomodulin; CD141; BDCA3; Fetomodulin; AHUS6
应用说明
应用建议
应用推荐稀释比
IHC-P2 - 5 µg/ml
WB1 - 2 µg/ml
应用说明IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Tris buffer with 1 mM EDTA (pH 9.0) for 10-20 min, followed by cooling at RT for 20 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA.
抗菌剂0.05% Sodium azide
稳定剂0.1 mg/ml BSA
浓度0.2 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 7056 Human THBD

Swiss-port # P07204 Human Thrombomodulin

基因名称THBD
全名thrombomodulin
背景介绍The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
生物功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [UniProt]
预测分子量60 kDa (unmodified); 100 kDa (glycosylated)
翻译后修饰N-glycosylated.

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. [UniProt]
检测图片 (4)
  • ARG58012 anti-Thrombomodulin antibody [THBD/1591] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human cervical carcinoma stained with ARG58012 anti-Thrombomodulin antibody [THBD/1591]. Antigen Retrieval: Boil tissue section in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 10-20 min followed by cooling at RT for 20 min.

  • ARG58012 anti-Thrombomodulin antibody [THBD/1591] WB image

    Western blot: 1) Recombinant partial protein and 2) THP-1 lysate stained with ARG58012 anti-Thrombomodulin antibody [THBD/1591].

  • ARG58012 anti-Thrombomodulin antibody [THBD/1591] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human bladder carcinoma stained with ARG58012 anti-Thrombomodulin antibody [THBD/1591]. Antigen Retrieval: Boil tissue section in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 10-20 min followed by cooling at RT for 20 min.

  • ARG58012 anti-Thrombomodulin antibody [THBD/1591] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human placenta stained with ARG58012 anti-Thrombomodulin antibody [THBD/1591]. Antigen Retrieval: Boil tissue section in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 10-20 min followed by cooling at RT for 20 min.

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