anti-Tissue Factor antibody [HTF-1] (PE)

产品描述: PE-conjugated Mouse Monoclonal antibody [HTF-1] recognizes Tissue Factor
反应物种: Hu
应用: FACS
特异性: The mouse monoclonal antibody HTF-1, also known as HTF1-7B8, recognizes an extracellular epitope of CD142 (tissue factor, coagulation factor III), a type I glycoprotein expressed on endothelial cells, monocytes, macrophages, and platelets upon induction by inflammatory mediators, and expressed constitutively by some tumors, the vasculature, placenta, kidney, and central nervous system.
宿主: Mouse
克隆: Monoclonal
克隆号: HTF-1
同位型: IgG1, kappa
靶点名称: Tissue Factor

CAT.NO. : ARG42308

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Size:

50 tests

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Product Details

概述

产品描述	PE-conjugated Mouse Monoclonal antibody [HTF-1] recognizes Tissue Factor
反应物种	Hu
应用	FACS
特异性	The mouse monoclonal antibody HTF-1, also known as HTF1-7B8, recognizes an extracellular epitope of CD142 (tissue factor, coagulation factor III), a type I glycoprotein expressed on endothelial cells, monocytes, macrophages, and platelets upon induction by inflammatory mediators, and expressed constitutively by some tumors, the vasculature, placenta, kidney, and central nervous system.
宿主	Mouse
克隆	Monoclonal
克隆号	HTF-1
同位型	IgG1, kappa
靶点名称	Tissue Factor
抗原物种	Human
抗原	Human brain tissue factor.
偶联标记	PE
別名	Thromboplastin; Tissue factor; TFA; CD142; TF; Coagulation factor III; CD antigen CD142

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 2152 Human F3 Swiss-port # P13726 Human Tissue factor
基因名称	F3
全名	coagulation factor III (thromboplastin, tissue factor)
背景介绍	This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
生物功能	Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. [UniProt]
细胞定位	Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt]
预测分子量	33 kDa

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