anti-TLR7 antibody [4F4]

CAT.NO. : ARG56919

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Size:

50 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [4F4] recognizes TLR7
反应物种	Hu
应用	FACS, ICC/IF, WB
宿主	Mouse
克隆	Monoclonal
克隆号	4F4
同位型	IgG1, kappa
靶点名称	TLR7
抗原物种	Human
抗原	Recombinant fragment around aa. 451-500 of Human TLR7.
偶联标记	Un-conjugated
別名	TLR7-like; Toll-like receptor 7

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	10% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 51284 Human TLR7 Swiss-port # Q9NYK1 Human Toll-like receptor 7
基因名称	TLR7
全名	toll-like receptor 7
背景介绍	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
生物功能	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). [UniProt]
预测分子量	121 kDa

检测图片 (3)

ARG56919 anti-TLR7 antibody [4F4] ICC/IF image
Immunoflorescense: THP-1 cell line stained with ARG56919 anti-TLR7 antibody [4F4] at 1:100 (Green).
DAPI (Blue) for nucleus staining.
ARG56919 anti-TLR7 antibody [4F4] FACS image
Flow Cytometry: THP-1 cell line stained with ARG56919 anti-TLR7 antibody [4F4] at 2-5 µg for 1x10^6 cells (red line). Secondary antibody: Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was Mouse IgG (black line).
ARG56919 anti-TLR7 antibody [4F4] WB image
Western blot: 80 µg of Ramos cell lysates stained with ARG56919 anti-TLR7 antibody [4F4] at 1:1000. Arrow indicates TLR7 protein in Human Ramos cells.

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