anti-Tollip antibody [k1B17]

CAT.NO. : ARG56967

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Size:

50 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [k1B17] recognizes Tollip
反应物种	Hu
应用	ICC/IF, WB
宿主	Mouse
克隆	Monoclonal
克隆号	k1B17
同位型	IgG2a, kappa
靶点名称	Tollip
抗原物种	Human
抗原	Recombinant fragment around aa. 61-274 of Human Tollip.
偶联标记	Un-conjugated
別名	Toll-interacting protein; IL-1RAcPIP

应用说明

应用建议

应用	推荐稀释比
ICC/IF	Assay-dependent
WB	1:500 - 1:1000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	10% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 54472 Human TOLLIP Swiss-port # Q9H0E2 Human Toll-interacting protein
基因名称	TOLLIP
全名	toll interacting protein
背景介绍	This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]
生物功能	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. [UniProt]
预测分子量	30 kDa
翻译后修饰	Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.

检测图片 (2)

ARG56967 anti-Tollip antibody [k1B17] ICC/IF image
Immunoflorescense: THP-1 cell line stained with ARG56967 anti-Tollip antibody [k1B17] at 1:100 (Green).
DAPI (Blue) for nucleus staining.
ARG56967 anti-Tollip antibody [k1B17] WB image
Western blot: 40 µg of 1) Jurkat cell lysate, 2) HepG2 cell lysate, 3) HeLa cell lysate stained with ARG56967 anti-Tollip antibody [k1B17] at 1:1000.

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