anti-TPP1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes TPP1
  • 反应物种: Hu
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: TPP1
  • 抗原物种: Human
  • 抗原: Synthetic peptide corresponding to aa. 227-261 of Human TPP1. (CAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVV)
  • Brand:
CAT.NO. : ARG42649
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes TPP1
反应物种Hu
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称TPP1
抗原物种Human
抗原Synthetic peptide corresponding to aa. 227-261 of Human TPP1. (CAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVV)
偶联标记Un-conjugated
別名EC 3.4.14.9; TPP-1; Tripeptidyl-peptidase I; GIG1; Lysosomal pepstatin-insensitive protease; SCAR7; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase 1; CLN2; LPIC; Cell growth-inhibiting gene 1 protein; TPP-I
应用说明
应用建议
应用推荐稀释比
IHC-P1:200 - 1:1000
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HeLa
实际分子量~ 61 kDa
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA.
抗菌剂0.05% Sodium azide
稳定剂5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1200 Human TPP1

Swiss-port # O14773 Human Tripeptidyl-peptidase 1

基因名称TPP1
全名tripeptidyl peptidase I
背景介绍This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
生物功能Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967). Requires substrates with an unsubstituted N-terminus (PubMed:19038966). [UniProt]
细胞定位Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [UniProt]
预测分子量61 kDa
翻译后修饰Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity. [UniProt]
检测图片 (2)
  • ARG42649 anti-TPP1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG42649 anti-TPP1 antibody at 1 µg/ml dilution.

  • ARG42649 anti-TPP1 antibody WB image

    Western blot: HeLa whole cell lysate stained with ARG42649 anti-TPP1 antibody at 0.5 µg/ml dilution.

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