anti-TRAF3 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes TRAF3
  • 反应物种: Hu, Ms, Rat
  • 应用: ELISA, ICC/IF, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: TRAF3
  • 抗原物种: Human
  • 抗原: Synthetic peptide (15 aa) within aa. 20-70 of Human TRAF3.
  • Brand:
CAT.NO. : ARG54694
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes TRAF3
反应物种Hu, Ms, Rat
应用ELISA, ICC/IF, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称TRAF3
抗原物种Human
抗原Synthetic peptide (15 aa) within aa. 20-70 of Human TRAF3.
偶联标记Un-conjugated
別名LMP1-associated protein 1; EC 6.3.2.-; CD40 receptor-associated factor 1; LAP1; CAP-1; CD40-binding protein; CAP1; CD40BP; IIAE5; CRAF1; CD40bp; TNF receptor-associated factor 3
应用说明
应用建议
应用推荐稀释比
ELISAAssay-dependent
ICC/IF10 μg/ml
WB2 - 4 μg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HeLa Cell Lysate
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS and 0.02% Sodium azide
抗菌剂0.02% Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 22031 Mouse TRAF3

GeneID: 362788 Human TRAF3

GeneID: 7187 Human TRAF3

基因名称TRAF3
全名TNF receptor-associated factor 3
背景介绍TRAF3 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily. TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1. Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κB. Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.
生物功能Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. [UniProt]
产品亮点Related products:
Anti-Rabbit IgG secondary antibodies;
Related poster download:
The NF-kappa B Pathways.pdf
研究领域Cancer antibody; Cell Death antibody; Immune System antibody; Signaling Transduction antibody
预测分子量64 kDa
翻译后修饰Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.
检测图片 (2)
  • ARG54694 anti-TRAF3 antibody WB image

    Western blot: HeLa cell lysate stained with ARG54694 anti-TRAF3 antibody at (A) 2 and (B) 4 ug/ml dilution.

  • ARG54694 anti-TRAF3 antibody ICC/IF image

    Immunocytochemistry: HeLa cells stained with ARG54694 anti-TRAF3 antibody at 10 ug/ml dilution.

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