anti-TRAF7 antibody
CAT.NO. : ARG40250
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概述
产品描述 | Rabbit Polyclonal antibody recognizes TRAF7 |
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反应物种 | Hu, Ms, Rat |
应用 | ICC/IF, IHC-P, WB |
宿主 | Rabbit |
克隆 | Polyclonal |
同位型 | IgG |
靶点名称 | TRAF7 |
抗原物种 | Human |
抗原 | Synthetic peptide of Human TRAF7. |
偶联标记 | Un-conjugated |
別名 | E3 ubiquitin-protein ligase TRAF7; RING finger and WD repeat-containing protein 1; EC 6.3.2.-; RFWD1; RING finger protein 119; TNF receptor-associated factor 7; RNF119 |
应用说明
预测反应性说明 | Human | ||||||||
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应用建议 |
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应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
阳性对照 | Mouse fetal stomach | ||||||||
实际分子量 | 65 kDa |
属性
形式 | Liquid |
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纯化 | Affinity purified. |
缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
抗菌剂 | 0.02% Sodium azide |
稳定剂 | 50% Glycerol |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | TRAF7 |
全名 | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
背景介绍 | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] |
生物功能 | E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. [UniProt] |
细胞定位 | Cytoplasmic vesicle. [UniProt] |
预测分子量 | 75 kDa |
翻译后修饰 | Phosphorylated by MAP3K3. Ubiquitinates itself upon phosphorylation. [UniProt] |
