anti-TRIM antibody [TRIM-04] (PE)
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Key features and details
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CAT.NO. : ARG53964
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [TRIM-04] recognizes TRIM |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Ms |
| 应用 | FACS |
| 特异性 | The clone TRIM-04 reacts with T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TRIM-04 |
| 同位型 | IgG2a |
| 靶点名称 | TRIM |
| 抗原物种 | Human |
| 抗原 | Recombinant intracellular domain (aa 29-186) of human TRIM. |
| 偶联标记 | PE |
| 別名 | TRIM; TCRIM; pp29/30; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; HSPC062 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q6PIZ9 Human T-cell receptor-associated transmembrane adapter 1 |
|---|---|
| 基因名称 | TRAT1 |
| 全名 | T cell receptor associated transmembrane adaptor 1 |
| 背景介绍 | TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear. |
| 生物功能 | Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. [UniProt] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | Phosphorylated on tyrosines by LCK or FYN upon TCR activation. |
检测图片 (1)
ARG53964 anti-TRIM antibody [TRIM-04] (PE) FACS image
Flow Cytometry: Human peripheral blood stained with ARG53964 anti-TRIM antibody [TRIM-04] (PE) and anti-CD3 antibody (APC).
参考文献
克隆号文献
Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.
WB / Human
Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells.
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
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