anti-TRIM33 / TIF1 gamma antibody

Key features and details

  • 产品描述: Mouse Monoclonal antibody recognizes TRIM33 / TIF1 gamma
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 同位型: IgG2a
  • 靶点名称: TRIM33 / TIF1 gamma
  • 抗原物种: Human
  • 抗原: Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.
  • Brand:
CAT.NO. : ARG54025
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Product Details
概述
产品描述Mouse Monoclonal antibody recognizes TRIM33 / TIF1 gamma
反应物种Hu
应用WB
宿主Mouse
克隆Monoclonal
同位型IgG2a
靶点名称TRIM33 / TIF1 gamma
抗原物种Human
抗原Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.
偶联标记Un-conjugated
別名TIF1GAMMA; Ectodermin homolog; EC 6.3.2.-; Transcription intermediary factor 1-gamma; TIFGAMMA; RET-fused gene 7 protein; E3 ubiquitin-protein ligase TRIM33; TIF1G; TIF1-gamma; Protein Rfg7; PTC7; RFG7; Tripartite motif-containing protein 33; ECTO; TF1G
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified
缓冲液0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol
抗菌剂0.2% Sodium azide
稳定剂50% Glycerol
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 51592 Human TRIM33

Swiss-port # Q9UPN9 Human E3 ubiquitin-protein ligase TRIM33

基因名称TRIM33
全名tripartite motif containing 33
背景介绍Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
生物功能Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). [UniProt]
细胞定位Nucleus
研究领域Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody
预测分子量123 kDa
翻译后修饰Sumoylated with SUMO1.
检测图片 (1)
  • ARG54025 anti-TRIM33 / TIF1 gamma antibody WB image

    Western blot: 30 µg of 293T and HeLa cell lysates stained with ARG54025 anti-TRIM33 / TIF1 gamma antibody at 1:1000 dilution.

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