anti-TRIM5 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes TRIM5
  • 反应物种: Hu
  • 应用: WB
  • 特异性: This antibody is expected to recognise all human isoforms of TRIM5.
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: TRIM5
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG44550
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes TRIM5
反应物种Hu
应用WB
特异性This antibody is expected to recognise all human isoforms of TRIM5.
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称TRIM5
抗原物种Human
抗原Synthetic peptide of Human TRIM5 (a.a. 34-84).
偶联标记Un-conjugated
別名TRIM5; Tripartite Motif Containing 5; RNF88; TRIM5alpha; RING-Type E3 Ubiquitin Transferase TRIM5; Tripartite Motif-Containing Protein 5; Tripartite Motif Protein TRIM5; Tripartite Motif-Containing Protein 5 Alpha; Tripartite Motif Protein TRIM; Tripartite Motif-Containing 5; Ring Finger Protein 88; RING Finger Protein 88
应用说明
应用建议
应用推荐稀释比
WB0.2-1 μg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量56, 35, 33 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS, 0.09% (w/v) Sodium azide and 2% Sucrose.
抗菌剂0.09% (w/v) Sodium azide
稳定剂2% Sucrose
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 85363 Human TRIM5

Swiss-port # Q9C035 Human Tripartite motif-containing protein 5

基因名称TRIM5
全名Tripartite Motif Containing 5
背景介绍The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
生物功能Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV).
细胞定位Cytoplasm, Nucleus
研究领域Cell Biology and Cellular Response antibody; Gene Regulation antibody; Immune System antibody
预测分子量56(alpha), 35(gamma), 33(delta),kDa
翻译后修饰Acetylation, Phosphoprotein, Ubl conjugation
检测图片 (1)
  • ARG44550 anti-TRIM5 antibody WB image

    Western blot: PANC1 stained with ARG44550 anti-TRIM5 antibody at 1 μg/ml dilution.

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