anti-TrkB antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes TrkB
  • 反应物种: Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: TrkB
  • 抗原物种: Rat
  • 抗原: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
  • Brand:
CAT.NO. : ARG52451
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes TrkB
反应物种Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称TrkB
抗原物种Rat
抗原Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
偶联标记Un-conjugated
別名TRKB; Neurotrophic tyrosine kinase receptor type 2; Trk-B; trk-B; Tropomyosin-related kinase B; TrkB tyrosine kinase; BDNF/NT-3 growth factors receptor; GP145-TrkB; EC 2.7.10.1
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明Specific for the ~93 kDa TrkB protein in Western blots.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
稳定剂0.1 mg/ml BSA, 50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 25054 Rat NTRK2

Swiss-port # Q63604 Rat BDNF/NT-3 growth factors receptor

基因名称Ntrk2
全名neurotrophic tyrosine kinase, receptor, type 2
背景介绍Tropomyosin-receptor-kinase (TRK) receptors are members of the receptor tyrosine kinase family and include TrkA, TrkB and TrkC. Each of these receptor types has different binding affinities to the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3). TrkB has the highest affinity to binding BDNF which plays critical roles in the function and survival of neurons in the CNS (Soppet et al., 1991; Klein et al., 1991). Additionally, alterations in expression of TrkB have been associated with Alzheimer’s disease (Ferrer et al., 1999; Chen et al., 2008).
研究领域Cancer antibody; Metabolism antibody; Neuroscience antibody
预测分子量92 kDa
翻译后修饰Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).
检测图片 (1)
  • ARG52451 anti-TrkB antibody WB image

    Western Blot: rat synaptic membrane preparation showing specific immunolabeling of the ~ 93k TrkB protein stained with ARG52451 TrkB antibody.

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