anti-Tropomyosin antibody [TM31]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [TM-311] recognizes Tropomyosin
  • 反应物种: Hu, Ms, Rat, Chk, Rb
  • 应用: IHC, WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: TM-311
  • 同位型: IgG1, kappa
  • 靶点名称: Tropomyosin
  • 抗原: Raised against purified gizzard Tropomyosin of chicken origin.
  • Brand:
CAT.NO. : ARG62652
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Product Details
概述
产品描述Mouse Monoclonal antibody [TM-311] recognizes Tropomyosin
反应物种Hu, Ms, Rat, Chk, Rb
应用IHC, WB
宿主Mouse
克隆Monoclonal
克隆号TM-311
同位型IgG1, kappa
靶点名称Tropomyosin
抗原Raised against purified gizzard Tropomyosin of chicken origin.
偶联标记Un-conjugated
別名C15orf13; Tropomyosin alpha-1 chain; TMSA; CMD1Y; HEL-S-265; HTM-alpha; CMH3; Tropomyosin-1; LVNC9; Alpha-tropomyosin
应用说明
应用建议
应用推荐稀释比
IHC1:50 - 1:100
WB1:100 - 1:200
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照LNCaP cells. Normal prostate or prostate carcinoma
属性
形式Liquid
纯化Purified Antibody
缓冲液1X PBS and 0.1% Sodium azide
抗菌剂0.1% Sodium azide
浓度0.2 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 100125989 Rabbit TPM1

GeneID: 22003 Mouse TPM1

GeneID: 24851 Rat TPM1

基因名称TPM1
全名tropomyosin 1 (alpha)
背景介绍This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
生物功能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. [UniProt]
研究领域Cell Biology and Cellular Response antibody; Signaling Transduction antibody
预测分子量33 kDa
翻译后修饰Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
检测图片 (1)
  • ARG62652 anti-Tropomyosin antibody [TM31] WB image

    Western blot: Rat skeletal muscle, Rat cardiac muscle, Mouse skeletal muscle, Mouse cardiac muscle and HeLa whole cell lysates stained with ARG62652 anti-Tropomyosin antibody [TM31] at 0.5 µg/ml dilution.

参考文献

克隆号文献

Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation.

WB / Mouse

Ito A et al.
Sci Rep.,  (2014)

publication_link

 

hr_line

Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms.

WB / Rabbit

Yamashiro S et al.
J Biol Chem.,  (2014)

publication_link

 

hr_line

Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia-reperfusion injury.

WB / Rat

Lin HB et al.
J Proteomics.,  (2012)

publication_link

 

hr_line

Functional evaluation of artificial skeletal muscle tissue constructs fabricated by a magnetic force-based tissue engineering technique.

WB / Mouse

Yamamoto Y et al.
Tissue Eng Part A.,  (2011)

publication_link

 

hr_line

Novel method for measuring active tension generation by C2C12 myotube using UV-crosslinked collagen film.

WB / Mouse

Fujita H et al.
Biotechnol Bioeng.,  (2010)

publication_link

 

hr_line
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