anti-TRPC6 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG51301
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TRPC6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TRPC6 |
| 抗原物种 | Human |
| 抗原 | peptide Corresponding to the amino terminal sequence derived from mouse TRPC6. |
| 偶联标记 | Un-conjugated |
| 別名 | FSGS2; Transient receptor protein 6; TrpC6; Short transient receptor potential channel 6; TRP-6; TRP6 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic peptide. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| 缓冲液 | PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q61143 Mouse Short transient receptor potential channel 6 Swiss-port # Q9Y210 Human Short transient receptor potential channel 6 |
|---|---|
| 基因名称 | Trpc6 |
| 全名 | transient receptor potential cation channel, subfamily C, member 6 |
| 背景介绍 | The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). |
| 生物功能 | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 106 kDa |
| 翻译后修饰 | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
检测图片 (2)
ARG51301 anti-TRPC6 antibody WB image
Western blot: 20 µg of A549 cell lysates stained with ARG51301 anti-TRPC6 antibody at 1:500 dilution.
ARG51301 anti-TRPC6 antibody WB image
Western blot: 20 µg of Mouse brain and Rat brain lysates stained with ARG51301 anti-TRPC6 antibody at 1:500 dilution.
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