anti-TSC1 / Hamartin antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG40883
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TSC1 / Hamartin |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms, Hm |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TSC1 / Hamartin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 1150-1164 of Human Hamartin (QLHIMDYNETHHEHS). |
| 偶联标记 | Un-conjugated |
| 別名 | LAM; Tuberous sclerosis 1 protein; Hamartin; TSC |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TSC1 |
| 全名 | tuberous sclerosis 1 |
| 背景介绍 | This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] |
| 生物功能 | In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. [UniProt] |
| 细胞定位 | Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes. [UniProt] |
| 预测分子量 | 130 kDa |
| 翻译后修饰 | Phosphorylation at Ser-505 does not affect interaction with TSC2. [UniProt] |
检测图片 (3)
ARG40883 anti-TSC1 / Hamartin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human mammary cancer tissue stained with ARG40883 anti-TSC1 / Hamartin antibody.
ARG40883 anti-TSC1 / Hamartin antibody WB image
Western blot: 50 µg of Rat skeletal muscle, Rat heart, Rat brain, Rat lung, 40 µg of 293T, HeLa, HT1080 and SMMC-7721 whole cell lysates stained with ARG40883 anti-TSC1 / Hamartin antibody at 0.5 µg/ml dilution.
ARG40883 anti-TSC1 / Hamartin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG40883 anti-TSC1 / Hamartin antibody.
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