anti-TTK / MPS1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58947
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TTK / MPS1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TTK / MPS1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 517-856 of Human TTK / MPS1 (NP_001160163.1). |
| 偶联标记 | Un-conjugated |
| 別名 | MPS1L1; Dual specificity protein kinase TTK; PYT; EC 2.7.12.1; MPH1; Phosphotyrosine picked threonine-protein kinase; MPS1; CT96; ESK |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse spleen | ||||||
| 实际分子量 | 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P33981 Human Dual specificity protein kinase TTK |
|---|---|
| 基因名称 | TTK |
| 全名 | TTK protein kinase |
| 背景介绍 | This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] |
| 生物功能 | Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. [UniProt] |
| 预测分子量 | 97 kDa |
检测图片 (1)
ARG58947 anti-TTK / MPS1 antibody WB image
Western blot: 25 µg of Mouse spleen lysate stained with ARG58947 anti-TTK / MPS1 antibody at 1:1000 dilution.
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