anti-UCP1 antibody

Key features and details

  • 产品描述: Goat Polyclonal antibody recognizes UCP1
  • 反应物种: Rat
  • 预测物种: Hu, Ms, Dog
  • 应用: WB
  • 宿主: Goat
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: UCP1
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG63944
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Product Details
概述
产品描述Goat Polyclonal antibody recognizes UCP1
反应物种Rat
预测物种Hu, Ms, Dog
应用WB
宿主Goat
克隆Polyclonal
同位型IgG
靶点名称UCP1
抗原物种Human
抗原C-EQLKRELSKSRQ
偶联标记Un-conjugated
別名UCP; SLC25A7; Thermogenin; Mitochondrial brown fat uncoupling protein 1; Solute carrier family 25 member 7; UCP 1
应用说明
应用建议
应用推荐稀释比
WB0.5 - 1 µg/ml
应用说明WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
缓冲液Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
抗菌剂0.02% Sodium azide
稳定剂0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 24860 Rat UCP1

Swiss-port # P04633 Rat Mitochondrial brown fat uncoupling protein 1

背景介绍Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
产品亮点Related products:
UCP1 antibodies; Anti-Goat IgG secondary antibodies;
Related news:
Has “Obesity gene” been found?
研究领域Cancer antibody; Metabolism antibody; Signaling Transduction antibody
预测分子量33 kDa
翻译后修饰May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.
May undergo ubiquitin-mediated proteasomal degradation.
检测图片 (2)
  • ARG63944 anti-UCP1 antibody WB image

    Western Blot: Human Adipose lysate (35 µg protein in RIPA buffer) stained with ARG63944 anti-UCP1 antibody at 1 µg/ml dilution.

  • ARG63944 anti-UCP1 antibody WB image

    Western blot: 35 µg of Rat adipose (A) and Rat skeletal muscle (B) lysates (in RIPA buffer) stained with ARG63944 anti-UCP1 antibody at 1 µg/ml (A) and 0.5 µg/ml (B) dilutions and incubated at RT for 1 hour.

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