anti-uPAR antibody [VIM5] (PE)
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Key features and details
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- 靶点名称:
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CAT.NO. : ARG42454
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [VIM5] recognizes uPAR |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody VIM5 recognizes CD87 (urokinase plasminogen activator receptor), a 36-68 kDa single-chain GPI-anchored extracellular glycoprotein expressed on granulocytes, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts and keratinocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | VIM5 |
| 同位型 | IgG1 |
| 靶点名称 | uPAR |
| 抗原物种 | Human |
| 抗原 | Human myeloid cell line THP-1. |
| 偶联标记 | PE |
| 別名 | Monocyte activation antigen Mo3; CD antigen CD87; uPAR; U-PAR; URKR; Urokinase plasminogen activator surface receptor; UPAR; CD87 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q03405 Human Urokinase plasminogen activator surface receptor |
|---|---|
| 基因名称 | PLAUR |
| 全名 | plasminogen activator, urokinase receptor |
| 背景介绍 | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. [UniProt] |
| 细胞定位 | Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted. [UniProt] |
| 预测分子量 | 37 kDa |
检测图片 (2)
ARG42454 anti-uPAR antibody [VIM5] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42454 anti-uPAR antibody [VIM5] (PE) at 10 µl / 100 µl of peripheral whole blood.
ARG42454 anti-uPAR antibody [VIM5] (PE) FACS image
Flow Cytometry: Separation of Human monocytes (red-filled) from lymphocytes (black-dashed). Human peripheral whole blood stained with ARG42454 anti-uPAR antibody [VIM5] (PE) at 10 µl / 100 µl of peripheral whole blood.
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