anti-UVRAG antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes UVRAG
  • 反应物种: Hu, Ms
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: UVRAG
  • 抗原物种: Human
  • 抗原: KLH-conjugated synthetic peptide corresponding to aa. 666-699 (C-terminus) of Human UVRAG.
  • Brand:
CAT.NO. : ARG54897
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes UVRAG
反应物种Hu, Ms
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称UVRAG
抗原物种Human
抗原KLH-conjugated synthetic peptide corresponding to aa. 666-699 (C-terminus) of Human UVRAG.
偶联标记Un-conjugated
別名VPS38; p63; DHTX; UV radiation resistance-associated gene protein
应用说明
应用建议
应用推荐稀释比
ICC/IF1:10 - 1:50
IHC-PAssay-dependent
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
缓冲液PBS and 0.09% (W/V) Sodium azide
抗菌剂0.09% (W/V) Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 7405 Human UVRAG

Swiss-port # Q9P2Y5 Human UV radiation resistance-associated gene protein

基因名称UVRAG
全名UV radiation resistance associated
背景介绍This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
细胞定位Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial
研究领域Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody
预测分子量78 kDa
翻译后修饰Phosphorylated at Ser-498 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7,A and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (PubMed:25533187).
检测图片 (2)
  • ARG54897 anti-UVRAG antibody ICC/IF image

    Immunofluorescence: U251 cells were treated with Chloroquine (50 µM, 16 h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then stained with ARG54897 anti-UVRAG antibody (green) at 1:200 dilution, 2 h at room temperature. Nuclei were counterstained with Hoechst 33342 (blue) (10 µg/ml, 5 min).

  • ARG54897 anti-UVRAG antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma tissue stained with ARG54897 anti-UVRAG antibody.

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