anti-VAV2 phospho (Tyr142) antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes VAV2 phospho (Tyr142) |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | This antibody detects endogenous levels of VAV2 protein only when phosphorylated at Tyr142. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | VAV2 |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Tyr142 (aa. 108-157) of Human VAV2. |
| 偶联标记 | Un-conjugated |
| 別名 | Guanine nucleotide exchange factor VAV2; VAV-2 |
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | K562 + TNF HeLa + TNF | ||||||||
| 实际分子量 | ~ 100 kDa |
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P52735 Human Guanine nucleotide exchange factor VAV2 Swiss-port # Q60992 Mouse Guanine nucleotide exchange factor VAV2 |
|---|---|
| 基因名称 | VAV2 |
| 全名 | vav 2 guanine nucleotide exchange factor |
| 背景介绍 | VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| 生物功能 | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). [UniProt] |
| 预测分子量 | 101 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to FGR activation. [UniProt] |
ARG66850 anti-VAV2 phospho (Tyr142) antibody WB image
Western blot: HeLa and K562 cells treated with TNF (20 ng/ml for 30 min). Cell lysates were stained with ARG66850 anti-VAV2 phospho (Tyr142) antibody. The lane on the right is blocked with the phospho peptide.
ARG66850 anti-VAV2 phospho (Tyr142) antibody ICC/IF image
Immunofluorescence: NIH/3T3 cells stained with ARG66850 anti-VAV2 phospho (Tyr142) antibody. The picture on the right is blocked with the phospho peptide.
ARG66850 anti-VAV2 phospho (Tyr142) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG66850 anti-VAV2 phospho (Tyr142) antibody. The picture on the right is blocked with the phospho peptide.
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