anti-WWTR1 / TAZ antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57876
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes WWTR1 / TAZ |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | WWTR1 / TAZ |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to a sequence within aa. 300 to the C-terminus of Human WWTR1 (NP_056287.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Transcriptional coactivator with PDZ-binding motif; WW domain-containing transcription regulator protein 1; TAZ |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9EPK5 Mouse WW domain-containing transcription regulator protein 1 Swiss-port # Q9GZV5 Human WW domain-containing transcription regulator protein 1 |
|---|---|
| 基因名称 | WWTR1 |
| 全名 | WW domain containing transcription regulator 1 |
| 生物功能 | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. [UniProt] |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. [UniProt] |
检测图片 (2)
ARG57876 anti-WWTR1 / TAZ antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG57876 anti-WWTR1 / TAZ antibody at 1:100 dilution.
ARG57876 anti-WWTR1 / TAZ antibody
Western blot: 25 µg of HeLa cell lysate stained with ARG57876 anti-WWTR1 / TAZ antibody at 1:1000 dilution.
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