Arginase-1 Rabbit Monoclonal Antibody(ARB874)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6666
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Product Details
Background
Argininase 1 (ARG-1) is a new hepatocyte marker and a key enzyme in the liver urea cycle. It is well expressed in normal hepatic nuclei, but not in other normal tissues, and is highly expressed in hepatocellular carcinoma with different degrees of differentiation. The better the differentiation is, the higher the positive rate is, and it is superior to HepPar 1 in poorly differentiated hepatocellular carcinoma. It is more sensitive than AFP and HepPar 1 in the diagnosis of hepatocellular carcinoma, and is often used in combination with Glypican3 for hepatocellular carcinoma and metastatic carcinoma. Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia.
Overview
| Target | Arginase-1 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 35 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P05089 |
| Immunogen | Synthetic peptide within Human Liver Arginase aa 300-400 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nucleus & Cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human hepatocellular carcinoma tissue sections using Arginase-1 Rabbit Monoclonal Antibody (ARB874).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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