arigoQIKTM Rat IL1 beta ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
- 标准范围:
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Brand:
CAT.NO. : ARG83522
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG83522-01 | Antibody Coated Microplate | 8 X 12 strips | 4°C |
| ARG83522-02 | Standard | 2 vials | 4°C |
| ARG83522-03 | 1000X HRP-Streptavidin solution | 15 μl | 4°C |
| ARG83522-04 | Standard/Sample Diluent Buffer | 20 ml | 4°C |
| ARG83522-05 | HRP Diluent Buffer | 20 ml | 4°C |
| ARG83522-06 | 10X Wash Buffer | 35 ml | 4°C |
| ARG83522-07 | TMB substrate | 12 ml | 4°C (protect from light) |
| ARG83522-08 | STOP solution | 12 ml | 4°C |
| ARG83522-09 | Plate sealer | 2 strips | Room temperature |
概述
| 产品描述 | ARG83522 arigoQIKTM Rat IL1 betaELISA Kit is an Enzyme Immunoassay kit for the quantification of Rat IL1 beta in serum, plasma and cell culture supernatants. |
|---|---|
| 反应物种 | Rat |
| 应用 | ELISA |
| 靶点名称 | IL1 beta |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 7.8 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 15.63 - 1000 pg/ml |
| 样本量 | 50 μL |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | IL1B; Interleukin 1 Beta; IL1F2 2; IL1-BETA; Interleukin-1 Beta; IL-1 Beta; Catabolin; IL-1B; Pro-Interleukin-1-Beta; Preinterleukin 1 Beta; Interleukin 1beta; IL1beta; IL-1 |
应用说明
| 检测时间 | 2 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 4°C, -20°C, -80°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL1B |
|---|---|
| 全名 | interleukin 1, beta |
| 背景介绍 | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
| 生物功能 | Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection. [Uniprot] |
| 细胞定位 | Cytoplasm, Lysosome, Secreted. [Uniprot] |
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