arigoQIKTM Rat IL4 ELISA Development Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
- 标准范围:
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CAT.NO. : ARG83549
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Product Details
概述
| 产品描述 | ARG83549 arigoQIKTM Rat IL4 ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Rat IL4 in serum, plasma and cell culture supernatants. For other reagents required for arigoQIKTM ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More about arigoQIKTM: ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available |
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| 反应物种 | Rat |
| 应用 | ELISA |
| 靶点名称 | IL4 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 3.91 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 7.81 - 500pg/ml |
| 样本量 | 50 μl |
| 精确 | Intra-Assay CV: Inter-Assay CV: |
| 別名 | IL4; Interleukin 4; IL-4; Lymphocyte Stimulatory Factor 1; BCGF-1; BCGF1; BSF1; B_cell Stimulatory Factor 1; B Cell Growth Factor 1; Interleukin-4; Binetrakin; Pitrakinra; MGC79402; BSF-1; B-Cell Stimulatory Factor 1 |
属性
| 存放说明 | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
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| 基因名称 | IL4 |
| 全名 | Interleukin 4 |
| 背景介绍 | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020] |
| 生物功能 | Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 翻译后修饰 | Disulfide bond, Glycoprotein. [UniProt] |
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