b-FGF Rabbit Monoclonal Antibody(ARA906)
Key features and details
- Reactivity:Human, Mouse
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:b-FGF
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Brand:
CAT.NO. : ARA6741
RMB Please choose
RMB Please choose
Product Details
Background
FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins. Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. In normal tissue, bFGF is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human FGF2 aa 121-170 / 288 |
|
Species Reactivity |
Human, Mouse |
|
Validated Applications |
WB, IP, FC, IHC-P |
|
Molecular Weight |
Predicted band size: 31 kDa |
|
Positive Control |
K-562 cell lysate, U-87 MG cell lysate, Hela cell lysate, 293T cell lysate, human breast tissue, human prostate tissue, mouse trachea tissue, Jurkat |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human prostate tissue using b-FGF Rabbit Monoclonal Antibody (ARA906)
Immunohistochemical staining of human breast tissue using b-FGF Rabbit Monoclonal Antibody (ARA906)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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