Bcl-2 Mouse Monoclonal Antibody(ARB878)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6670
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Product Details
Background
B - Cell Lymphoma 2 (BCL2) is involved in regulation of cell apoptosis by controlling mitochondrial permeability and release of cytochrome c. It also has critical roles in normal cell physiology related to neuronal activity, autophagy, calcium handling, mitochondrial dynamics, and energetics. BCL2 overexpression has been shown to promote cell survival by suppressing apoptosis, and is found to be correlated with poor disease prognosis in breast, prostate, ovarian, endometrial, and colon cancers. In follicular lymphoma, Anti - BCL2 reacts negatively with germinal centers and positively with neoplastic follicles. In lymphoid lesions, BCL2 staining is useful for distinguishing reactive and neoplastic follicular proliferations, and for identifying minimal residual disease in the bone marrow of follicular lymphoma patients. BCL2 is now a useful target of human cancer therapy.
Overview
| Target | BCL-2 |
| Host Species | mouse monoclonal antibody |
| Molecular Weight | 26 kDa |
| Purity | ProG affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P10415 |
| Immunogen | Synthetic peptide of Human BCL-2 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -20°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 minutes |
Data
Immunohistochemical staining of human tonsillar tissue sections using Bcl-2 Mouse Monoclonal Antibody (ARB878).
Immunohistochemical staining of human follicular lymphoma tissue sections using Bcl-2 Mouse Monoclonal Antibody (ARB878).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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