BCL-2 Mouse Monoclonal Antibody(ARM910)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1
- Target Name:BCL-2
- Research use only.
-
Brand:
CAT.NO. : ARM6700
RMB Please choose
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Product Details
Background
B - Cell Lymphoma 2 (BCL2) is involved in regulation of cell apoptosis by controlling mitochondrial permeability and release of cytochrome c. It also has critical roles in normal cell physiology related to neuronal activity, autophagy, calcium handling, mitochondrial dynamics, and energetics. BCL2 overexpression has been shown to promote cell survival by suppressing apoptosis, and is found to be correlated with poor disease prognosis in breast, prostate, ovarian, endometrial, and colon cancers. In follicular lymphoma, Anti - BCL2 reacts negatively with germinal centers and positively with neoplastic follicles. In lymphoid lesions, BCL2 staining is useful for distinguishing reactive and neoplastic follicular proliferations, and for identifying minimal residual disease in the bone marrow of follicular lymphoma patients. BCL2 is now a useful target of human cancer therapy.
Application
IHC: 1:50-1:200
Overview
|
OMIM |
151430 |
|
3D Structure |
ModBase 3D Structure for P10415 |
|
Clonality |
Monoclonal |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Species Reactivity |
Human |
|
Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Hodgkin’s Lymphoma sections labeling BCL2 with ARM910.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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