Bcl-6 Rabbit Monoclonal Antibody(ARB880)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6672
RMB Please choose
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.The mitogen-activated protein kinases, Erk1 and Erk2, but not JNK, phosphorylate BCL6 at multiple sites. Phosphorylation of BCL6 at Ser333 and Ser343 results in degradation of BCL6 by the ubiquitin/proteasome pathway in B cells. In addition, BCL6 is acetylated and its transcriptional repressor function is inhibited by the transcriptional co-activator p300. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease. Bcl-6 combined with CD10 can be used to distinguish follicular lymphoma from other lymphomas. Bcl-6 combined with CD10 and MUM1 can be used for the classification of diffuse large B-cell lymphoma.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100 - 1:200 |
Overview
|
Host Species |
rabbit monoclonal antibody |
|
Molecular Weight |
79 kDa |
|
Purity |
ProA affinity purified IgG |
|
Species Cross-reactivity |
Human |
|
Form |
Liquid |
|
Applications |
IHC-P |
|
Swissprot ID |
P41182 |
|
Immunogen |
Recombinant protein fragment |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
|
Subcellular Location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human tonsillar tissue sections using Bcl-6 Rabbit Monoclonal Antibody (ARB880).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
for Research Use Only. Not for use in diagnostic procedures.
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