BCOR Rabbit Polyclonal Antibody

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Polyclonal
Target:BCOR

Brand:

CAT.NO. : ARA6777

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Size:

1mL 100μL

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Product Details

Background

BCL6 corepressor protein (BCOR) is a ubiquitously expressed transcriptional repressor that is recruited to target genes by BCL6 and other transcription factors. BCOR interacts with recruits histone deacetylase (HDAC) and DNA methyltransferase (DNMT) proteins to facilitate localized histone deacetylation and DNA methylation, resulting in repression of gene expression. Mutations and translocations involving BCOR have been observed in acute myeloid leukemia, bone sarcoma and medulloblastoma and mutations in BCOR are known to cause X-linked Oculofaciocardiodental and Lenz microphthalmia syndromes. The BCOR gene is localised at Xp11.4 and plays an important role in normal early embryonic development. Expressed in a variety of tumours such as rhabdomyosarcoma, ossifying fibromucinous tumour subtype (lacking S100 expression), CNS PNET, retinoblastoma, medulloblastoma, haematological malignancies, renal clear-cell sarcoma with BCOR gene abnormality or UWHAE-NUTM2 fusion and high-grade endometrial mesenchymal sarcoma. The diagnosis of high-grade endometrial mesenchymal sarcoma with ZC3H7B-BCOR gene fusion is often made in combination with CD10 and CyclinD1.

Application

Application	Dilution Ratio
IHC-P	1:50-1:100

Overview

Immunogen	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCOR. The exact sequence is proprietary.
Purification Method	The antibody was purified by immunogen affinity chromatography.
Clone Type	Polyclonal
Product Form	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Gene Name	BCOR
Related Names	KIAA1575; BCL-6 corepressor; BCoR