BRCA1 Mouse Monoclonal Antibody(ARA861)

Key features and details

Reactivity:Human
Application:IHC
Host:Mouse
Clonality:Monoclonal
Target:BRCA1

Brand:

CAT.NO. : ARA6687

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Size:

1mL

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Product Details

Background

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Application

Application	Dilution Ratio
IHC-P	1:100-1:500

Overview

Antibody Type	Mouse Monoclonal Antibody
Immunogen	Recombinant protein
Species Reactivity	Human
Molecular Weight	208 kDa
Positive Control	Human BRCA1 recombinant protein, BRCA1-hIgGFc transfected HEK293 cell lysate, human esophagus cancer tissue, human esophagus tissue
Conjugation	unconjugated
Form	Liquid
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide
Isotype	IgG1
Purification Method	Protein A affinity purified