c-Myc Rabbit Monoclonal Antibody(ARB925)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6717
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Size:
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Product Details
Background
Oncogene-encoded proteins c-Myc, n-Myc, and l-Myc function in cell proliferation, differentiation, and neoplastic disease. A mutated version of Myc is found in many cancers, causing Myc to be constitutively expressed, leading to unregulated expression of genes involved in cell proliferation and cancer formation. c-Myc is a transcription factor and a proto-oncogene, critical in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis. A common human translocation involving Myc is t(8;14), which is critical to the development of most cases of Burkitt's Lymphoma. Malfunctions in Myc are also found in carcinomas of the cervix, colon, breast, lung, and stomach.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 48kDa |
| Species Cross-reactivity | Human |
| Applications | HIC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P01106 |
| Subcellular location | Nucleus |
| Recommended method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Immunogen | Synthetic peptide residues in human c-Myc |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human lymphoma tissue using c-Myc Rabbit Monoclonal Antibody (ARB925).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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