Calreticulin Rabbit Monoclonal Antibody(ARB888)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6680
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Product Details
Background
Calcium is a universal signaling molecule involved in many cellular functions, such as cell motility, metabolism, protein modification, et al. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin. Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. Calreticulin is expressed in all kinds of normal tissues and tumor tissues. Calreticulin purified from tumor can stimulate the anti-tumor immune response of the body, the possible mechanism is that the calreticulin molecule binds to the tumor antigen polypeptide, and in the process of calreticulin into the cell membrane, the tumor antigen peptide bound with it is brought to the cell membrane and presented to the antigen-presenting cell, thus stimulating the anti-tumor immune effect of the body. Calreticulin purified from tumor can stimulate the anti-tumor immune response of the body, the possible mechanism is that the calreticulin molecule binds to the tumor antigen polypeptide, and in the process of calreticulin into the cell membrane, the tumor antigen peptide bound with it is brought to the cell membrane and presented to the antigen-presenting cell, thus stimulating the anti-tumor immune effect of the body.
Overview
| Target | Calreticulin |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 48 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P27797 |
| Immunogen | Synthetic peptide |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human lung adenocarcinoma tissue sections using Calreticulin Rabbit Monoclonal Antibody (ARB888).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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