CaSR Mouse Monoclonal Antibody (6D4)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB, IP, IF
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1K
- Target Name:CaSR
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Brand:
CAT.NO. : ARA0064
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Product Details
Background
Extracellular calcium - sensing receptor (CaSR), also designated parathyroid cell calcium - sensing receptor, is an integral membrane protein that belongs to the G protein - coupled receptor three family. CaSR is involved in maintaining a stable calcium concentration by acting as an sensor of the extracellular calcium levels for the parathyroid and kidney. Its activity is mediated by a G protein which activates a phosphatidylinositol - calcium second messenger system. Defects that activate CaSR cause autosomal dominant hypocalcemia, whereas mutations that inactivate the protein cause familial hypocalciuric hypercalcemia. CaSR is expressed mainly in kidney, and is also expressed in intestine, placenta and brain.
Application
CaSR (6D4) is recommended for detection of CaSR of mouse, rat, human and rabbit origin by Western Blotting (starting dilution 1:200, dilution range 1:100 - 1:1000), immunoprecipitation [1 - 2 µg per 100 - 500 µg of total protein (1 ml of cell lysate)] and immunofluorescence (starting dilution 1:50, dilution range 1:50 - 1:500).
Data
CaSR (6D4). Western blot analysis of CaSR expression in rat brain (A) and rat placenta (B) tissue extracts.
Simultaneous direct near - infrared western blot analysis of CaSR expressionn, detected with CaSR (6D4) Alexa Fluor® 680 and α - actin (H - 2) Alexa Fluor® 790 in rat placenta tissue extract.
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