Cathepsin D Rabbit Monoclonal Antibody(ARA902)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:Cathepsin D
-
Brand:
CAT.NO. : ARA6737
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Deficiency of CTSD gene has been reported an underlying cause of neuronal ceroid lipofuscinosis (NCL).
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:3000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human Cathepsin D aa 363-412 / 412 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IF-Cell, IHC-P, IP |
|
Molecular Weight |
Predicted band size: 45/28 kDa |
|
Positive Control |
HepG2 cell lysate, MCF7 cell lysate, Neuro-2a cell lysate, Mouse brain tissue lysate, C6 cell lysate, Rat brain tissue lysate, human breast cancer tissue, human pancreas tissue, PANC-1, AGS |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human breast cancer tissue using Cathepsin D Rabbit Monoclonal Antibody (ARA902)
Immunohistochemical staining of human pancreas tissue using Cathepsin D Rabbit Monoclonal Antibody (ARA902)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
