CD105 Monoclonal Antibody(ARB599)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:CD105
-
Brand:
CAT.NO. : ARB6893
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
CD105(Endoglin) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. It is a transmembrane protein that exists as a disulfide-linked homodimer. CD105 is restricted to endothelial cells in all tissues except bone marrow. Upregulated CD105 expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in CD105 have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100-1:200 |
Overview
|
Predicted Molecular Wt |
71kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
SwissProt ID |
P27813 |
|
Subcellular location |
Membrane |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes. |
|
Immunogen |
Synthetic peptide. |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of liver cancer using CD105 Monoclonal Antibody(ARB599)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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