CD117 Rabbit Monoclonal Antibody(ARB837)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6627
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Product Details
Background
CD117 is a cell membrane protein encoded by the c-kit proto-oncogene (chromosome 4q11-12). The protein is a type III tyrosine kinase growth factor receptor for stem cell factor (SCF), also known as mast cell growth factor. CD117 is required for the development and growth of a large number of cells expressing this protein.
CD117 is expressed in mast cells, melanocytes and interstitial cells of Cajal (ICC). The cells (particularly the mast cells) show a strong membrane as well as cytoplasmic staining. CD117 moreover is expressed in various epithelia (breast, sweat glands and salivary glands, renal tubular cells, thyroid follicular cells), usually showing a weaker, cytoplasmic reaction. In tumor tissues, CD117 is expressed in most cases of Gastrointestinal stromal tumor (GIST), mast cell neoplasms, malignant melanoma (however, the expression of CD117 is lost during progression and metastasising), seminoma/dysgerminoma and intratubular germ cell neoplasia, endometrial carcinoma, follicular and papillary thyroid carcinoma, Merkel cell carcinoma, cylindroma, malignant glioma, and angiomyolipoma.CD117 may be useful for the classification of several cancers expressing c-kit, including gastrointestinal stromal tumors (GISTs), mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing's sarcoma.
CD117 is expressed in mast cells, melanocytes and interstitial cells of Cajal (ICC). The cells (particularly the mast cells) show a strong membrane as well as cytoplasmic staining. CD117 moreover is expressed in various epithelia (breast, sweat glands and salivary glands, renal tubular cells, thyroid follicular cells), usually showing a weaker, cytoplasmic reaction. In tumor tissues, CD117 is expressed in most cases of Gastrointestinal stromal tumor (GIST), mast cell neoplasms, malignant melanoma (however, the expression of CD117 is lost during progression and metastasising), seminoma/dysgerminoma and intratubular germ cell neoplasia, endometrial carcinoma, follicular and papillary thyroid carcinoma, Merkel cell carcinoma, cylindroma, malignant glioma, and angiomyolipoma.CD117 may be useful for the classification of several cancers expressing c-kit, including gastrointestinal stromal tumors (GISTs), mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing's sarcoma.
Overview
| Target | CD117 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 110 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P10721 |
| Immunogen | Synthetic peptide corresponding to CD117 residues within aa876-976 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane & Cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human appendiceal tissue sections was performed using CD117 Rabbit Monoclonal Antibody (ARB837).
Immunohistochemical staining of human gastrointestinal stromal tumor (GIST) tissue sections was performed using CD117 Rabbit Monoclonal Antibody (ARB837).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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