CD11c Rabbit Monoclonal Antibody(ARA881)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:CD11c R
-
Brand:
CAT.NO. : ARA6708
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:400-1:1000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human CD11c aa 1114-1163 / 1163 (Cytoplasmic) |
|
Species Reactivity |
Human |
|
Validated Applications |
WB, IHC-P, rpIHC, IF-Tissue |
|
Molecular Weight |
Predicted band size: 128 kDa |
|
Positive Control |
Human Hodgkin's lymphoma tissue, human spleen tissue, human lymph nodes tissue, human colon cancer tissue, human liver tissue, human cervical cancer, human tonsil |
|
Conjugation |
unconjugated |
|
RRID |
AB_3069725 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue with CD11c Rabbit Monoclonal Antibody(ARA881)
Immunohistochemical analysis of paraffin-embedded human Hodgkin's lymphoma tissue with CD11c Rabbit Monoclonal Antibody(ARA881)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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