CD19 Rabbit Monoclonal Antibody(ARB893)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6685
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Product Details
Background
The human CD19 antigen is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily, which initiates a series of biological responses that are likely to be of central importance to B-cell signaling and/or growth regulation and the development of a humoral immune response.CD19 is specifically expressed in normal and neoplastic B cells, as well as follicular dendritic cells. In normal tissues, it is expressed from pre-B cells until the terminal differentiation to plasma cells. And in tumors, its expression is highly conserved on most B cell tumors. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas.CD19 is one of the most reliable surface biomarker for B cells and the CD19 monoclonal antibodies have been explored for lymphoma therapy.
Overview
| Target | CD19 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 61 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P15391 |
| Immunogen | Synthetic peptide corresponding to CD19 residues within aa456-556 of CD19 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
data
Immunohistochemical staining of human tonsil tissue sections using CD19 Rabbit Monoclonal Antibody (ARB893).
Immunohistochemical staining of human diffuse large B-cell lymphoma (DLBCL) tissue sections using CD19 Rabbit Monoclonal Antibody (ARB893).
storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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