CD1a Rabbit Monoclonal Antibody(ARB894)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6686
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Product Details
Background
CD1a is a member of the family group 1 CD1 proteins (CD1a, CD1b, and CD1c), which share the capacity to present microbial lipid antigens to cells.
CD1a is expressed predominantly on Langerhans cells (LCs), it can be expressed by T-cells under certain conditions. Immature thymocytes express CD1a, as do some T-cells involved in neoplastic conditions such as pre-lymphoblastic lymphomas/leukemias and follicular dendritic cell sarcoma.
CD1a expression on pathogenic Langerhans cells (LCs) in LCH is regarded as a hallmark of this disease and may as a potential target for future therapeutic strategies against inflammatory skin diseases.
CD1a is expressed predominantly on Langerhans cells (LCs), it can be expressed by T-cells under certain conditions. Immature thymocytes express CD1a, as do some T-cells involved in neoplastic conditions such as pre-lymphoblastic lymphomas/leukemias and follicular dendritic cell sarcoma.
CD1a expression on pathogenic Langerhans cells (LCs) in LCH is regarded as a hallmark of this disease and may as a potential target for future therapeutic strategies against inflammatory skin diseases.
Overview
| Target | CD1a |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 37 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P06126 |
| Immunogen | Synthetic peptide corresponding to CD1a residues within aa1-100 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
data
Immunohistochemical staining of human thymus tissue sections using CD1a Rabbit Monoclonal Antibody (ARB894).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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