CD4 Rabbit Monoclonal Antibody(ARB909)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6701
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
The CD4 molecule is a glycoprotein, belonging to immunoglobulin superfamily that is associated with HLA class II antigen recognition. It is a co - receptor that assists the T - cell receptor (TCR) with an antigen - presenting cell and also interacts directly with MHC class II molecules on the surface of the antigen - presenting cells using its extracellular domain. In lymphatic tissues, the CD4+ T cells are seen in large numbers in the parafollicular zone, while scattered cells are found in the germinal centres and mantle zone. CD4 is also demonstrated in hepatic sinusoidal cells, monocytes and monocytes - derived cells but not expressed on B cells and immature thymocytes. Most mature T - cell lymphomas are CD4 positive with the exception of aggressive NK - cell leukaemia and extranodal NK/T - cell lymphomas: subcutaneous panniculitis - like T - cell lymphoma (which is usually CD8 positive), enteropathy - type T - cell lymphoma and hepatosplenic T - cell lymphoma. CD4 is also expressed in histiocytic sarcomas and Langerhans cell histiocytosis as well as in splenic littoral cell haemangioma. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Target |
CD4 |
|
Host Species |
rabbit monoclonal antibody |
|
Molecular Weight |
51 kDa |
|
Purity |
ProA affinity purified IgG |
|
Species Cross-reactivity |
Human |
|
Form |
Liquid |
|
Applications |
IHC-P |
|
Swissprot ID |
P01730 |
|
Immunogen |
Synthetic peptide corresponding to CD4 residues within aa200-300 |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
|
Storage Conditions |
-25°C to -18°C |
|
Dilutions |
IHC-P: 1:100-1:200 |
|
Subcellular Location |
Membrane |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18° C-25° C) for 30 minutes |
Data
Immunohistochemical staining of human tonsil tissue sections using CD4 Rabbit Monoclonal Antibody (ARB909).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
